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Medchemexpress LLC Tlr7/8/9-in-1 | 2180127-82-4 | 98.5% | C27H37N3O2 | 10MG
Supplier: Medchemexpress LLC HY13195210MG
TLR7/8/9-IN-1 is a potent, orally bioavailable small-molecule antagonist of Toll-like receptors 7, 8, and 9 intended for research use in immunology and inflammation studies. It inhibits TLR-mediated signaling in cellular assays and demonstrates low-nanomolar antagonist activity in PBMCs, supporting mechanistic and preclinical investigations.
- Potent antagonist with IC50 = 43 nM against TLR7/8/9.
- Low-nanomolar activity in PBMCs (TLR7 IC50 = 4.8 nM; TLR9 IC50 = 510 nM).
- Orally bioavailable small molecule suitable for in vivo and in vitro studies.
- High purity (98.51%) appropriate for biochemical assays.
- Available as solid and as 10 mM in DMSO solutions for flexible dosing.
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