Cayman Chemical TMBhydrochlorIde hydrate 100mg

Supplier:  Cayman Chemical 70450100 MG

A pan-Clk inhibitor (IC50s 0.67 15 and 110 nM for Clk1 Clk2 and Clk3 respectively) selective for Clk1-3 over DYRK1A and DYRK1B (IC50s 260 and 230 nM respectively) as well as 62 kinases in a panel at 1000 nM and four kinases in the same panel at 1110 nM reduces exon recognition and increases conjoined gene transcription in HCT116 colorectal cancer cells and 184-hTERT mammary epithelial cells reduces VEGFR2 expression HUVECs at 300-1000 nM inhibits VEGF-induced-sprouting in HUVEC spheroids at 300 and 1000 nM inhibits HUVEC migration at 500 800 and 1000 nM

Catalog No. 50-289-4311