Medchemexpress LLC TMP195 | 1314891-22-9 | 99.8% | 456.42 | 250 MG

Supplier:  Medchemexpress LLC 250MGHY18361

TMP195 is a selective class IIa histone deacetylase (HDAC) inhibitor. It has reported Ki values of 59, 60, 26, and 15 nM for HDAC4, HDAC5, HDAC7, and HDAC9, respectively. It is intended for research use only and not for sale to patients.

• Selective class IIa HDAC inhibitor.
• Blocks the accumulation of CCL2 protein in monocyte-derived macrophage differentiation cultures.
• Significantly increases CCL1 protein secretion by monocytes.
• Occupies the acetyllysine-binding site of class IIa HDACs.
• Alters the tumor microenvironment, reducing tumor burden and pulmonary metastases by modulating macrophage phenotypes in vivo.
• Induces recruitment and differentiation of highly phagocytic and stimulatory macrophages within tumors in vivo.
• Combining with chemotherapy regimens or T-cell checkpoint blockade enhances the durability of tumor reduction in vivo.

Catalog No. 50-003-84398