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Apexbio Technology LLC TMP269 1314890-29-3 10mM (in 1mL DMSO)
SDP

Supplier:  Apexbio Technology LLC A88065.1

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TMP269 (CAS 1314890-29-3) is a selective inhibitor of class IIa histone deacetylases (HDACs) specifically targeting HDAC isoforms 4 5 7 and 9 with IC50 values of 126 80 36 and 9 nM respectively HDACs catalyze removal of acetyl groups from histone lysine residues thereby condensing chromatin and repressing transcription TMP269 induces moderate cytotoxicity (IC50 22-38 M) in multiple myeloma cell lines correlating with cleavage of caspase-3 -8 -9 and PARP and enhances ER stress-induced apoptosis signaling pathways Additionally TMP269 inhibits PKD1-mediated proliferation in intestinal epithelial IEC-18 cells

Catalog No. 50-000-62122


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