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Enzo Life Sciences TNC : TWEAK (soluble) (mouse), (recombinant) (10µg)
SDP

Supplier:  Enzo Life Sciences ALX522138C010

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Some TNF ligands (such as TWEAK (mouse) or FasL (mouse)) produced as soluble forms do not assemble into stable trimers and show low receptor binding. Addition of the tenascin-C oligomerization domain (TNC) (from chicken) at the N-terminus of recombinant mouse soluble TWEAK stabilizes the TNF homology domain (THD) of rmsTWEAK into a trimer and increases binding to its respective TNF receptor. Alternative name: Apo-3L, TNFSF 12. Concentration: 0.1mg/ml after reconstitution. Purity: ≥95% (SDS-PAGE). Formulation: Lyophilized. Contains PBS. Source: Produced in HEK 293 cells. The extracellular domain of mouse TWEAK (aa 94-249) is fused at the N-terminus to tenascin-C (TNC) (chicken) (aa 110-139) and a FLAG-tag. Specificity: Binds to Fn14 (mouse):Fc (human) (rec.) (ALX-522-036). Applications: ELISA .

Catalog No. 50-200-9450


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