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AdipoGen TNF-alpha Soluble h rec
Supplier: AdipoGen AG40B0006C050
Protein. A FLAG -tag is fused at the N-terminus of human TNF-alpha aa 85-223. Source E. coli. Endotoxin content <0.01EU/µg purified protein LAL test Lonza. Lyophilized. Contains PBS. Binds to human and mouse TNF-R1. Purity >95% SDS-PAGE. Tumor necrosis factor TNF, cachexin or cachectin and formerly known as tumor necrosis factor-alpha is a cytokine involved in systemic inflammation and is a member of a group of cytokines that stimulate the acute phase reaction. The receptor TNF-R1 is activated by both the membrane-bound and soluble trimeric forms of TNF-alpha, whereas the receptor TNF-R2 only responds to the membrane-bound form of TNF-alpha MultimericTNF-alpha Prod. No. AG-40B-0019. Since the MultimericTNF-alpha mimics the membrane-bound form forms oligomers higher than trimer, it is the only TNF-alpha protein that can activate the TNF-R2. For TNF-R1 activation, either "normal" TNF-alpha or MultimericTNF-alpha can be used.
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