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Genscript Corporation Antibody Protein Proteins Proteins 1 MG 1/EA
Supplier: Genscript Corporation Z033751
TNF is secreted by macrophages monocytes neutrophils T-cells NK-cells following their stimulation by bacterial LPS. Cells expressing CD4 secrete TNF-alpha while CD8 cells secrete little or no TNF-alpha. The synthesis of TNF-alpha is induced by many different stimuli including interferons IL2 GM-CSF. TNF-beta is a potent mediator of inflammatory and immune responses. It belongs to the TNF family of ligands and signals through TNFR1 and TNFR2. TNF-beta is produced by activated T and B lymphocytes and has similar activities to TNF-Alpha. It mediates a large variety of inflammatory immunostimulatory and antiviral responses.
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