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AdipoGen TNFalpha msmultimericrec
Supplier: AdipoGen AG40B0021C010
Protein. The extracellular domain of mouse TNF-alpha aa 77-235 is fused at the N-terminus to mouse ACRP30headless aa 18-111 and a FLAG -tag. Source HEK 293 cells. Endotoxin content <0.02EU/µg purified protein LAL test Lonza. Lyophilized. Contains PBS. Binds to human and mouse TNF-R1 and TNF-R2. Purity >95% SDS-PAGE. Tumor necrosis factor TNF, cachexin or cachectin and formerly known as tumor necrosis factor-alpha is a cytokine involved in systemic inflammation and is a member of a group of cytokines that stimulate the acute phase reaction. MultimericTNF-alpha™ is a high activity construct in which two trimeric TNF-alpha ligands are artificially linked via the collagen domain of ACRP30. The receptor TNF-R1 is activated by both the membrane-bound and soluble trimeric forms of TNF-alpha, whereas the receptor TNF-R2 only responds to the membrane-bound form of TNF-alpha TNF-alpha mouse multimeric rec. Prod. No. AG-40B-0021.
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