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Cayman Chemical TNP-ATPsodIum salt 3.6mg
Supplier: Cayman Chemical 384923.6 MG
A derivative of ATP and an antagonist of the purinergic P2Y1, P2X3, and P2X2/3 receptors (IC50s = 6, 0.9, and 7 nM, respectively, in HEK293 cells expressing the human receptors); selective for these receptors over the purinergic P2X2, P2X4, and P2X7 receptors (IC50s = 2, 15.2, and >30 µM, respectively, in HEK293 cells expressing the human receptors); decreases acetic acid-induced calcium flux in 1321N1 cells expressing the P2X3 and P2X2/3 receptors (IC50s = 100 and 62 nM, respectively); reduces the number of abdominal constrictions induced by acetic acid in a mouse model of visceral pain (ED50 = 6.35 µmol/kg); ex/em maxima 403 and 547 nm, respectively; relative fluorescence increases four-fold when bound to IDE with an em maxima at 538 nm
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