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Tocris Bioscience™ AF 12198
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Catalog No. 17931
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17-931 1 mg
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Catalog No. 17-931 Supplier Tocris Bioscience™ Supplier No. 1793/1
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Description

Potent, selective human type I IL-1 receptor antagonist

AF 12198 is a potent and selective antagonist for the human type I interleukin-1 (IL-1) receptor (IC50 values are 8 nM, > 6.7 mM and > 200 mM for human type I, human type II and murine type I IL-1 receptors respectively). Blocks IL-1-induced expression of ICAM-1 and E-selectin in HUVECs and IL-1β induction of IL-8 in human dermal fibroblasts. Reduces IL-1β-induced IL-6 production and exhibits anti-inflammatory activity in vivo.

Specifications

Purity 0.95
Content And Storage Store at -20°C
Quantity 1 mg
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