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Apexbio Technology LLC Tolbutamide 64-77-7 1g
Supplier: Apexbio Technology LLC B21941000
Tolbutamide (CAS 64-77-7) is a small molecule inhibitor known to suppress cyclic adenosine monophosphate (cAMP)-dependent protein kinase activity with an IC50 value of 4 mM It reduces both basal and cAMP-stimulated kinase activities in cellular models including soluble and membrane-bound forms from canine cardiac tissue In adipose tissue tolbutamide s inhibition of cAMP-dependent protein kinase underlies its reported suppression of lipolysis Additionally tolbutamide has been shown to increase connexin43 mRNA levels while decreasing Ki-67 expression in glioma cells suggesting roles in cell proliferation studies This compound is used in research focused on kinase signaling and metabolic regulation
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