Tolbutamide, 98%

Description

CAS: 64-77-7 | C12H18N2O3S | 270.347 g/mol

Tolbutamide, have been used in a cDNA microarray assay to probe changes in gene expression in HepG2 cells upon their administration. It has been utilized to counteract insulin activity in a patch-clamp investigation of ATP sensitive K+ channels in mouse pancreatic β-cells. The activity of various biotransformation enzymes in cultured primary rat proximal tubular cells in the presence of tolbutamide and other compounds has been studied.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
Tolbutamide, have been used in a cDNA microarray assay to probe changes in gene expression in HepG2 cells upon their administration. It has been utilized to counteract insulin activity in a patch-clamp investigation of ATP sensitive K+ channels in mouse pancreatic β-cells. The activity of various biotransformation enzymes in cultured primary rat proximal tubular cells in the presence of tolbutamide and other compounds has been studied.

Solubility
Soluble in chloroform.

Notes
Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Store away from oxidizing agent.

Specifications

Chemical Identifiers

• CAS: 64-77-7
• Molecular Formula: C12H18N2O3S
• Molecular Weight (g/mol): 270.347
• MDL Number: MFCD00027169
• InChI Key: JLRGJRBPOGGCBT-UHFFFAOYSA-N
• Synonym: tolbutamide, orinase, 1-butyl-3-tosylurea, tolbutamid, aglicid, arkozal, artosin, diabetol, dolipol, rastinon
• PubChem CID: 5505
• ChEBI: CHEBI:27999
• IUPAC Name: 1-butyl-3-(4-methylphenyl)sulfonylurea
• SMILES: CCCCNC(=O)NS(=O)(=O)C1=CC=C(C=C1)C

• Melting Point: 128°C to 130°C
• Quantity: 10 g
• Beilstein: 1984428
• Merck Index: 14,9507
• Solubility Information: Soluble in chloroform.
• Formula Weight: 270.35
• Percent Purity: 98%
• Chemical Name or Material: Tolbutamide

Safety and Handling

Hazard Category	H302-H317
Hazard Statement	GHS H Statement H302-H317 Harmful if swallowed. May cause an allergic skin reaction.
Precautionary Statement	P261-P264b-P270-P272-P280g-P301+P312-P302+P352-P330-P333+P313-P363-P501c
EINECSNumber	200-594-3
RTECSNumber	YS4550000
TSCA	Yes
Recommended Storage	Ambient temperatures

SDS

RUO – Research Use Only