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Apexbio Technology LLC Tolvaptan 150683-30-0 5mg
Supplier: Apexbio Technology LLC B23005
Tolvaptan (CAS 150683-30-0) is a selective orally active antagonist of the arginine vasopressin (AVP) V2 receptor In binding assays using HeLa cells expressing human AVP receptor subtypes tolvaptan exhibits high affinity for the V2 receptor (Ki 0 43 nM) and substantially lower affinity for the V1a receptor (Ki 12 3 nM) with minimal activity at V1B and other off-target receptors or ion channels Tolvaptan inhibits AVP-induced cAMP accumulation with an IC50 of 8 nM In animal models administration of tolvaptan increases urine output and serum sodium and elevates plasma sodium while reducing mortality in hyponatremic rats This compound is widely utilized in research exploring water balance AVP signaling and hyponatremia mechanisms
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