Medchemexpress LLC Tomatidine hydrochloride | 6192-62-7 | 50 MG

Supplier:  Medchemexpress LLC HYN2149A50MG

Tomatidine hydrochloride acts as an anti-inflammatory agent by blocking NF-κB and JNK signaling. It also activates autophagy in mammal cells or C elegans. In vitro, Tomatidine decreases inducible NO synthase and COX-2 expression by suppressing I-κBα phosphorylation, NF-κB nuclear translocation, and JNK activation, which subsequently inhibits c-jun phosphorylation and Oct-2 expression. It causes dose-dependent inhibition of LPS-induced iNOS expression and suppresses the binding activity of NF-κB.

• Acts as an anti-inflammatory agent
• Blocks NF-κB and JNK signaling pathways
• Activates autophagy in mammal cells or C elegans
• Decreases inducible NO synthase and COX-2 expression
• Inhibits I-κBα phosphorylation and NF-κB nuclear translocation
• Suppresses JNK activation and c-jun phosphorylation
• Inhibits LPS-induced iNOS expression
• Suppresses NF-κB binding activity

Catalog No. 50-004-21622