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Cayman Chemical TopIramate-d12 10mg
SDP

Supplier:  Cayman Chemical 2644310 MG

Encompass_Preferred

An orally bioavailable potent and selective EP4 receptor antagonist (IC50 16.3 nM in a human EP4 functional assay) selective for EP4 with IC50 values of 2.4 1890 20000 and 20000 nM for binding to human EP4 EP2 EP1 and EP3 respectively has potent binding affinity for human rat and dog EP4 (Kis 0.97 6.1 and 38 nM respectively suppresses PGE2-induced elevation of intracellular cAMP in vitro (pA2 1.1 nM) reduces carrageenan-induced mechanical hyperalgesia in rats in a dose-dependent manner

Catalog No. 50-293-3740


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