Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More
Learn More
Apexbio Technology LLC Topotecan 123948-87-8 10mM (in 1mL DMSO)
Supplier: Apexbio Technology LLC B49825.1
Topotecan (CAS 123948-87-8) a semisynthetic derivative of camptothecin functions by selectively inhibiting topoisomerase I This inhibition stabilizes enzyme-DNA cleavage complexes disrupting DNA replication and transcription processes essential for tumor cell proliferation In preclinical studies topotecan demonstrated antitumor activity in mouse models of leukemia (P388) Lewis lung carcinoma B16 melanoma and human colon adenocarcinoma xenograft HT-29 Its toxicity primarily affecting rapidly proliferating tissues such as bone marrow and gastrointestinal epithelium was concentration-dependent and reversible Topotecan is employed extensively as a research tool in oncology studies focusing on DNA-topoisomerase interactions and targeting solid tumor growth
Product Title
By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.
Spot an opportunity for improvement?