Apexbio Technology LLC Topotecan HCl 119413-54-6 10mM (in 1mL DMSO)

Supplier:  Apexbio Technology LLC B22965.1

Topotecan HCl (CAS 119413-54-6) also known as SKF104864 is a semisynthetic derivative of camptothecin functioning as a selective inhibitor of topoisomerase I It stabilizes the topoisomerase I-DNA cleavage complex causing DNA damage and subsequent cell death Preclinical studies in murine tumor models demonstrate notable antitumor activity particularly against intravenous P388 leukemia and Lewis lung carcinoma when administered intravenously or in subcutaneous xenografts Additionally it exhibits efficacy against solid tumors including drug-resistant cancers and HT-29 human colon carcinoma xenografts Toxicological evaluations indicate reversible and concentration-dependent toxic effects primarily impacting rapidly proliferating tissues such as bone marrow and gastrointestinal epithelium

Catalog No. 50-000-62615