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Topotecan hydrochloride, Tocris Bioscience™
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Quantity:
10 mg
50 mg
Description
Topotecan hydrochloride is a DNA topoisomerase I inhibitor; induces rapid apoptotic death in human B-lineage acute lymphoblastic leukemia (ALL) cells. Improves survival in three mouse models of poor prognosis ALL; downregulates B-Myb and MycN expression in neuroblastoma cells. Water-soluble analog of Camptothecin (Cat. No. 1100). Orally bioavailable. Topotecan disrupts the interaction between NHP2L1 and U4 RNA by binding to U4 and inhibits RNA splicing.
Specifications
Quantity | 10 mg |
Formula Weight | 457.91 |
Percent Purity | >98% |
Chemical Name or Material | Topotecan hydrochloride |
Safety and Handling
Recommended Storage | Store at -20°C |
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