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Apexbio Technology LLC Torin 2 1223001-51-1 200mg
SDP

Supplier:  Apexbio Technology LLC B1640200

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Torin 2 (CAS 1223001-51-1) is a selective orally bioavailable inhibitor of the mammalian target of rapamycin (mTOR) exhibiting an EC50 of approximately 0 25 nM Structurally improved from Torin 1 Torin 2 interacts via hydrogen bonding with residues V2240 and Y2225 in mTOR and two additional interactions between its aniline amino group and residues D2195 and D2357 enhancing potency and pharmacokinetic properties It displays high selectivity for mTOR over phosphoinositide 3-kinases (PI3Ks) and other protein kinases by nearly 800-fold Due to these properties Torin 2 is extensively studied in oncological research targeting mTOR signaling pathways

Catalog No. 50-000-63385


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