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Selleck Chemical LLC Tozasertib (VX-680) S1048-250mg
Supplier: Selleck Chemical LLC S1048250MG
Tozasertib (VX-680) is a pan-Aurora inhibitor mostly against Aurora A with Kiapp of 0 6 nM in a cell-free assay less potent towards Aurora B/Aurora C and 100-fold more selective for Aurora A than 55 other kinases The only exceptions are Fms-related tyrosine kinase-3 (FLT-3) and BCR-ABL tyrosine kinase which are inhibited by the Tozasertib with both Ki of 30 nM Tozasertib induces apoptosis and autophagy Phase 2
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