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Medchemexpress LLC TP0427736 hydrochloride | 2459963-17-6 | 99.2% | 334.85 | C14H11ClN4S2 | 100 MG
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Supplier:  Medchemexpress LLC HY118528A100MG

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TP0427736 hydrochloride is a research-grade small-molecule inhibitor of the TGF-β type I receptor kinase (ALK5) used for biochemical and cell-based studies. It potently inhibits ALK5 kinase activity and reduces Smad2/3 phosphorylation in cellular assays, making it suitable for research on TGF-β/Smad signaling and related applications.

  • Potent ALK5 inhibition, IC50 = 2.72 nM.
  • Cellular activity: inhibits Smad2/3 phosphorylation in A549 cells, IC50 = 8.68 nM.
  • High reported purity (99.22%).
  • Supplied as the hydrochloride salt; available in research pack sizes including 100 mg.
  • Molecular weight 334.85 g·mol-1; formula C14H11ClN4S2.

Catalog No. 50-002-28591


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