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Medchemexpress LLC Tp0427736 hydrochloride | 2459963-17-6 | 99.2% | 334.85 | C14H11ClN4S2 | 50 MG
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Supplier:  Medchemexpress LLC HY118528A50MG

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TP0427736 hydrochloride is the hydrochloride salt of a potent ALK5 (TGF-β type I receptor) kinase inhibitor for in vitro and preclinical research. It inhibits ALK5 with low-nanomolar potency and reduces Smad2/3 phosphorylation in cellular assays.

  • Potent ALK5 inhibitor (ALK5 IC50 2.72 nM).
  • Selective over ALK3 (ALK3 IC50 836 nM).
  • Reduces Smad2/3 phosphorylation in A549 cells induced by TGF-β1 (8.68 nM).
  • Molecular weight 334.85.
  • Chemical formula C14H11ClN4S2.
  • Purity 99.22%.
  • Solid supplied as a 50 mg vial for laboratory research.

Catalog No. 50-002-28593


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