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Enzo Life Sciences TPEN (100mg). CAS: 16858-02-9
Supplier: Enzo Life Sciences ALX450011M100
A cell permeable and extremely high-affinity chelator of heavy metals, yet with low affinity for Mg2+ and Ca2+. Lipid-soluble, crossing both natural and artificial membranes. TPEN can be used in conjunction with QUIN 2 (ENZ-52013) or QUIN 2/AM to reduce heavy-metal quenching of QUIN 2 fluorescence in cells. Ion specificity: Zn2+>Fe2+>Mn2+>>Ca2+=Mg2+. Complex with Fe2+ catalyzes superoxide dismutation. Induces DNA fragmentation when chelated with Zn2+ and induces apoptosis in T cells. Alternative name: N,N,N',N'-Tetrakis-(2-pyridylmethyl)ethylenediamine. Purity: ≥97% (Nonaqueous Titration). Solubility: Soluble in dimethyl formamide, DMSO, 100% ethanol or methanol. Long Term Storage: +4°C.
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