Medchemexpress LLC Tpl2 kinase inhibitor 1 | 871307-18-5 | 99.4% | 404.83 g/mol | C21H14ClFN6 | 1MG

Supplier:  Medchemexpress LLC HY123581MG

Tpl2 Kinase Inhibitor 1 is a selective small-molecule inhibitor of Tpl2 (MAP3K8) for use in biochemical and cell-based studies of inflammatory signaling and oncology-related pathways. It inhibits recombinant Tpl2 with an IC50 of 50 nM and reduces LPS-induced TNF-α production in human monocytes and whole blood. The compound is supplied as a yellow to green solid with high chemical purity for research applications.

• Selective Tpl2 inhibition with IC50 of 50 nM.
• Cellular activity reducing LPS-induced TNF-α (monocytes IC50 = 0.7 μM; whole blood IC50 = 8.5 μM).
• High purity suitable for assays (≈99.4%).
• Molecular formula C21H14ClFN6; molecular weight 404.83 g/mol.
• Physical form: yellow to green solid.
• Storage: powder -20°C; in solvent -80°C (6 months) or -20°C (1 month).
• Applications: biochemical kinase assays and cell-based signaling studies.

Catalog No. 50-002-38843