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Medchemexpress LLC Tpl2 kinase inhibitor 1 | 871307-18-5 | MFCD10566771 | >95.0% | 404.83 g/mol | C21H14ClFN6 | 25MG
Supplier: Medchemexpress LLC HY1235825MG
Tpl2 kinase inhibitor 1 is a selective small-molecule inhibitor of Tpl2 (MAP3K8) used as a research reagent to probe MAP3K-dependent signaling and inflammatory responses. It inhibits Tpl2 with high potency and reduces lipopolysaccharide-induced TNF-α production in cellular and whole-blood assays. Supplied as a powder, it is soluble in DMSO and intended for laboratory research use only.
- Selectively inhibits Tpl2 with an IC50 of 50 nM.
- Reduces LPS-induced TNF-α production in primary human monocytes (IC50 = 0.7 μM) and whole blood (IC50 = 8.5 μM).
- Molecular formula C21H14ClFN6; molecular weight 404.83 g/mol.
- Supplied as a powder; soluble in DMSO at 100 mg/mL (may require sonication).
- Intended for laboratory research use only.
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