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AURORA BIOLABS LLC TR-FRET PARP1 Trapping Assay Kit,384 rxn
Supplier: AURORA BIOLABS LLC 72771TAK384
PARP1 (Poly ADP-ribose Polymerase 1) is a key DNA repair enzyme that detects DNA damage and facilitates repair through PARylation, a process in which PARP1 uses NAD⁺ to add poly (ADP-ribose) chains to itself and other proteins. PARP1 activity recruits DNA repair factors to damaged sites and supports genome stability. PARP1 is frequently overexpressed in several cancers, including breast, ovarian, prostate, and lung cancers, making it an important therapeutic target. Some PARP inhibitors not only block PARP1 catalytic activity but also trap PARP1 on damaged DNA, preventing DNA repair and leading to cancer cell death, particularly in BRCA-mutant tumors. The TR-FRET PARP1 Trapping Assay Kit is designed to quantitatively measure PARP1-DNA trapping activity and evaluate compounds that modulate PARP1 binding and trapping for cancer research and drug discovery applications.
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