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Medchemexpress LLC Tracazolate hydrochloride | 1135210-68-2 | 99.2% | 5 MG
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Supplier:  Medchemexpress LLC HYB1803A5MG

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Tracazolate (ICI 136753) hydrochloride is a potent GABAA receptor modulator with selectivity for β3, exhibiting anxiolytic and anticonvulsant activity. Its potency is determined by the nature of the third subunit (γ1-3, δ, ε) within the receptor complex. This compound is for research use only and not sold to patients.

  • Potentiates α1β1γ2s (EC50=13.2 μM) and α1β3γ2 (EC50=1.5 μM).
  • Inhibits α1β1ε (EC50=4.0 μM), α1β3ε (EC50=1.2 μM), α1β3 (EC50=2.7 μM), and α6β3γ (EC50=1.1 μM).
  • Interacts with γ-aminobutyric acid GABAA receptors, adenosine receptors, and phosphodiesterases.
  • Increases maximum current amplitude and enhances sensitivity of α1β2δ-containing GABAA receptors in oocytes at 10 μM.

Catalog No. 50-004-12848


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