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ABclonal Technology TRAF6 Rabbit mAb
Supplier: ABclonal Technology A2338520UL
The protein encoded by this gene is a member of the TNF receptor-associated factor (TRAF) protein family mediating signal transduction from the TNF receptor superfamily and the Toll IL-1 family It contains a RING domain four zinc-finger motifs a coiled-coil region and a TRAF-C domain This protein transduces signals from receptors like CD40 TNFSF11 and IL-1 and interacts with kinases such as IRAK1 SRC and PKCzeta linking different signaling pathways It plays a key role in the NF-kappaB pathway by activating IkappaB kinase (IKK) in response to proinflammatory cytokines This process requires its interaction with ubiquitin conjugating enzymes UBE2N UBC13 and UBE2V1 Additionally it interacts with the TGF beta receptor complex for Smad-independent activation of JNK and p38 kinases playing a vital role in antiviral and immune responses
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