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Genscript Corporation Antibody Protein Proteins Proteins 50 UG 1/EA
Supplier: Genscript Corporation Z0312450
TRAIL/Apo2L also known as Tumor Necrosis Factor Super-Family 10 (TNFSF10) is a pleiotropic cytokine thatbelongs to the TNF superfamily. The full length TRAIL expressed in vivo is a Type II transmembrane protein although the soluble form also exists and functions. TRAIL has four major receptors: two death receptors DR4 and DR5 two decoy receptors DcR1 and DcR2. TRAIL binds to the death receptors recruits the FAS-associated death domain activates caspases 8 and 10 and eventually leads to apoptosis. Because of its antitumor potential TRAIL is actively studied as a therapeutic agent. On the other hand abnormal expression of TRAIL in small arteries can induce the proliferation of smooth muscle cells resulting in increasing vascular remodeling and pulmonary arterial hypertension.
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