Apexbio Technology LLC Trametinib DMSO solvate 1187431-43-1 10mM (in 1mL DMSO)

Supplier:  Apexbio Technology LLC A38875.1

Trametinib DMSO solvate (CAS 1187431-43-1) is a potent allosteric inhibitor of MEK1 and MEK2 that acts through an ATP-noncompetitive mechanism In preclinical models it has demonstrated broad antitumor activity notably in colorectal cancer cell lines such as HT-29 and COLO205 Trametinib induces the expression of p15 and p27 suppresses cyclin D1 promotes RB dephosphorylation and G1 cell cycle arrest and reduces thymidylate synthase expression Furthermore it inhibits ERK1/2 phosphorylation leading to growth suppression in B-RAF mutant tumor cells Trametinib serves as a valuable tool for studying MAPK pathway signaling and targeted cancer therapeutics

Catalog No. 50-000-93201