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Medchemexpress LLC trans-AUCB (t-AUCB) | 885012-33-9 | 98.2% | 412.52 | 1 MG
SDP

Catalog No. 5000436747
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trans-AUCB (t-AUCB) is a potent, orally active, and selective soluble epoxide hydrolase (sEH) inhibitor with IC50s of 1.3 nM, 8 nM, and 8 nM for hsEH, mouse sEH, and rat sEH, respectively. It also demonstrates anti-glioma activity.

  • Potent, orally active, and selective soluble epoxide hydrolase (sEH) inhibitor.
  • IC50s: 1.3 nM (hsEH), 8 nM (mouse sEH), and 8 nM (rat sEH).
  • Possesses anti-glioma activity.
  • Suppresses U251 and U87 cell growth in a dose-dependent manner.
  • Induces cell-cycle G0/G1 phase arrest in U251 and U87 cells.
  • Increases phosphorylation levels of p65.
  • Suppresses U251 and U87 cell growth by activating NF-jB-p65.
  • Efficiently inhibits sEH activities in human glioblastoma cell lines (U251, U87) and human hepatocellular carcinoma cell line (HepG2 cells).
  • Ameliorates LPS-induced hypotension in a dose-dependent manner in mice.

Catalog No. 50-004-36747 Supplier Medchemexpress LLC Supplier No. HY1139741MG
May include imposed supplier surcharges.
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trans-AUCB (t-AUCB) is a potent, orally active, and selective soluble epoxide hydrolase (sEH) inhibitor with IC50s of 1.3 nM, 8 nM, and 8 nM for hsEH, mouse sEH, and rat sEH, respectively. It also demonstrates anti-glioma activity.

  • Potent, orally active, and selective soluble epoxide hydrolase (sEH) inhibitor.
  • IC50s: 1.3 nM (hsEH), 8 nM (mouse sEH), and 8 nM (rat sEH).
  • Possesses anti-glioma activity.
  • Suppresses U251 and U87 cell growth in a dose-dependent manner.
  • Induces cell-cycle G0/G1 phase arrest in U251 and U87 cells.
  • Increases phosphorylation levels of p65.
  • Suppresses U251 and U87 cell growth by activating NF-jB-p65.
  • Efficiently inhibits sEH activities in human glioblastoma cell lines (U251, U87) and human hepatocellular carcinoma cell line (HepG2 cells).
  • Ameliorates LPS-induced hypotension in a dose-dependent manner in mice.

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