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Medchemexpress LLC trans-Cyclohexane-1,2-diol | 1460-57-7 | 99.9% | 116.16 | 50 G
SDP

Catalog No. 5000451874
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trans-Cyclohexane-1,2-diol (TCHD) is a transient dilator of the nuclear pore complex (NPC). It interacts with the hydrophobic core (FG nucleoporin) of the NPC, which disrupts the NPC structure and reversibly increases the permeability of the nuclear pore. This allows macromolecules larger than 40 kDa, such as plasmid DNA, to enter the cell nucleus by passive diffusion, thereby enhancing the nuclear import efficiency of non-viral vectors.

  • Can improve the efficiency of in vitro electrotransfection or lipid-mediated gene transfection.
  • Significantly increases gene expression in differentiated airway epithelial cells.

Catalog No. 50-004-51874 Supplier Medchemexpress LLC Supplier No. HYW01051450G
May include imposed supplier surcharges.
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trans-Cyclohexane-1,2-diol (TCHD) is a transient dilator of the nuclear pore complex (NPC). It interacts with the hydrophobic core (FG nucleoporin) of the NPC, which disrupts the NPC structure and reversibly increases the permeability of the nuclear pore. This allows macromolecules larger than 40 kDa, such as plasmid DNA, to enter the cell nucleus by passive diffusion, thereby enhancing the nuclear import efficiency of non-viral vectors.

  • Can improve the efficiency of in vitro electrotransfection or lipid-mediated gene transfection.
  • Significantly increases gene expression in differentiated airway epithelial cells.

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