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Medchemexpress LLC Tranylcypromine (hydrochloride) | 1986-47-6 | 99.9% | 169.66 | 500 MG
Supplier: Medchemexpress LLC HY17447A500MG
Tranylcypromine hydrochloride is an irreversible inhibitor of lysine-specific demethylase 1 (LSD1/BHC110) and monoamine oxidase (MAO). It inhibits LSD1, MAO A, and MAO B with IC50s of 20.7, 2.3, and 0.95 μM, respectively. This compound can be used for research related to depression.
- Irreversible inhibitor of LSD1/BHC110 and MAO.
- Inhibits MAO-A with an IC50 of 2.3 μM.
- Inhibits MAO-B with an IC50 of 0.95 μM.
- Inhibits LSD1 with an IC50 of 20.7 μM.
- Potential use in depression research.
- Inhibits histone and nucleosomal demethylation.
- Shows specific derepression of OCT4 transcription.
- Decreases LPS-mediated microglial activation and proinflammatory cytokine COX-2 and IL-6 levels in wild-type mice.
- Down-regulates Aβ-mediated microglial activation in 5xFAD mice.
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