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Medchemexpress LLC Trazodone hydrochloride | 25332-39-2 | 99.6% | 1 ML
SDP

Supplier:  Medchemexpress LLC HYB047810MM/1ML

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Trazodone hydrochloride is a triazolopyridine derivative that functions as a serotonin receptor antagonist and reuptake inhibitor (SARI). It is recognized for its anti-depressant and anti-insomnious properties, exerting antagonistic effects against α1- and α2-adrenergic receptors and histamine H1 receptors with minimal anticholinergic impact.

  • Binds to 5-HT1A receptor with a Ki of 23.6 nM.
  • Reduces expression of neuroinflammatory markers.
  • Increases mRNA expression of BDNF and CREB.
  • Reduces IFN-γ release in neuronal-like cells.
  • Increases levels of phosphorylated ERK1/2 and decreases phosphorylated p38 levels.
  • Reduces spontaneous motor activity in cats and dogs.
  • Inhibits nicotine- and oxotremorine-induced tremor.
  • Decreases spontaneous firing rate of DR 5-HT neurons and blocks 5-HT reuptake.

Catalog No. 50-004-09206


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