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AdipoGen TRB-3 human pAb
Supplier: AdipoGen AG25A0059C100
Polyclonal Antibody. Recognizes human TRB-3. Detects a band of ~28kDa by Western blot predicted 39kDa. Source Rabbit. Applications ELISA, IHC, WB. Liquid. 0.2µm-filtered solution in PBS, pH 7.4. Contains no preservatives. Tribbles homolog 3 TRB-3 is a pseudokinase, shown to act as a potent negative regulator of PPARgamma, a master regulator of adipocyte differentiation, and to control adipogenesis. It disrupts insulin signaling by binding directly to Akt kinases and blocking their activation. It interacts also with the NF-kappaB transactivator p65 RELA. May play a role in programmed neuronal cell death but does not appear to affect non-neuronal cells.
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