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Cayman Chemical TreprostInIldIethnolamIn 10mg
SDP

Supplier:  Cayman Chemical 1192710 MG

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An agonist of IP2, DP2, and EP2 receptors; binds selectively to IP2, DP2, and EP2 over EP1, EP3, and EP4 receptors (Kis = 32, 4.4, 3.6, 212, 2,505, and 826 nM, respectively, in radioligand binding assays); inhibits LPS-induced production of TNF-α, IL-1β, IL-6, and GM-CSF in in isolated human alveolar macrophages at 200 ng/ml; relaxes isolated small pulmonary arteries and veins precontracted with U-46619; reduces right ventricular systolic pressure compared to hypoxic and sham control animals in a mouse model of chronic hypoxic pulmonary hypertension

Catalog No. 50-295-3115


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