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Apexbio Technology LLC Tretinoin (Aberela) 302-79-4 10mM (in 1mL DMSO)
Supplier: Apexbio Technology LLC A85395.1
Tretinoin (Aberela) is a pharmacologically active derivative of vitamin A (retinoic acid) widely utilized in biomedical research primarily for its therapeutic effects against acne vulgaris and keratosis follicularis At the cellular level tretinoin increases intracellular reduced glutathione levels and enhances catalase enzyme activity thus helping ameliorate oxidative stress caused by hydrogen peroxide in renal mesangial cell models It modulates inflammatory responses by suppressing expression of TNF- 1 and osteopontin proteins in renal tissue of aged rat models and regulates immunity in murine models by inhibition of lymphocyte proliferation and IL-17 secretion coupled with enhanced IL-10 production Additionally topical application in acne treatment research investigates its anti-inflammatory properties in combination formulations
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