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Medchemexpress LLC Tri-GalNAc-DBCO | 2999748-27-3 | 100.0% | 1730.94 | 25 MG
Supplier: Medchemexpress LLC 25MGHY148476
Tri-GalNAc-DBCO is a synthetic ligand composed of three GalNAc units connected to DBCO. It acts as a ligand for the sialic acid-degrading protein receptor (ASGPR) and can be coupled with targeting proteins or small molecules to form GalNAc-LYTACs. Tri-GalNAc-DBCO specifically binds to ASGPR and, through receptor-mediated endocytosis, guides the coupled molecules to lysosomes for degradation.
- Specifically binds to ASGPR, leading to receptor-mediated endocytosis and lysosomal degradation of coupled molecules.
- Can be conjugated with various targeting proteins or small molecules to create GalNAc-LYTACs.
- In vitro studies show it can be conjugated with anti-EGFR antibody, anti-HER2 antibody, and anti-PCSK9 antibody to form homogeneous conjugates capable of efficiently degrading membrane proteins.
- Offered at 99.97% purity.
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