U-Blot Pan-Tri-Methyllysine Rabbit pAb (peptide immunogen) is a Rabbit-derived polyclonal antibody that specifically recognizes Tri-Methyllysine a lysine trimethylation modification at Lys(K) It shows reactivity with Human Mouse Rat Validated applications include WB Recommended dilutions WB 1500-1000 Purified by protein a and immunogen affinity purified Histones undergo a wide range of enzyme-catalyzed post-translational modifications including acetylation methylation phosphorylation and ubiquitination Lysine trimethylation is a vital epigenetic modification that predominantly occurs on histone lysine residues It is dynamically regulated by histone methyltransferases and demethylases and extensively distributed in eukaryotic chromatin Lysine trimethylation participates in governing chromatin structure remodeling transcriptional activation or repression cell cycle regulation and DNA damage repair Supplied as 100 uL