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Medchemexpress LLC Triacetin | 102-76-1 | 99.6% | 1 ML
Supplier: Medchemexpress LLC HYB089610MM/1ML
Triacetin (Glyceryl triacetate) is a synthetic, orally active compound that increases acetate bioavailability in glioma cells. It induces glioma cell growth arrest and apoptosis, freely crossing the blood brain barrier/plasma membrane. This compound also increases histone acetylation and enhances the chemotherapeutic efficacy of Temozolomide. It is intended for research use only.
- Induces growth arrest in various glioma cells
- Inhibits U87MG cell viability
- Induces apoptosis in GBM cancer cells
- Decreases class I and II HDAC mRNA expression
- Inhibits HDAC-8 activity
- Activates mTOR complexes downstream genes
- Increases tumor suppressor miRs
- Enhances chemotherapeutic efficacy with Temozolomide
- Increases survival in animal models with GBM-derived GSCs
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