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Cayman Chemical TrIbenosIde 100mg
Supplier: Cayman Chemical 33498100 MG
A dopamine D3 receptor agonist selectively binds to the dopamine D3 over the D2 D1 and D4 receptors (Kis 0.78 61 650 and 5300 nM respectively in radioligand binding assays) increases calcium mobilization in HEK293 cells expressing the D3 receptor (EC50 13.5 nM in a FLIPR assay) decreases the release of striatal dopamine and DOPAC in rats at 0.25 mg/kg i.p. reduces the loss of ipsilateral SNC dopaminergic neurons in a rat model of 6-OHDA-induced Parkinsons disease at 2 Ug/Ul for eight weeks i.c.v. decreases amphetamine-induced ipsilateral rotations and increases the number of steps reached with the contralateral paw in the staircase test in the same model
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