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  6. Sigma Aldrich Trichloromethyl Chloroformate 

Sigma Aldrich Trichloromethyl Chloroformate

Catalog No. 2326110ML Shop All MilliporeSigma Sigma Organic Chemistry Products
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Description

MilliporeSigma Sigma Organics products encompass a wide range of quality reagents, solvents, catalysts, and building blocks for organic synthesis. From benchtop discovery to process development and scale-up, Sigma Organics solutions are built to meet the needs of synthetic chemists.

Trichloromethyl chloroformate (TCF) is an effective alternative to phosgene. It can react with amines, amino acids and amino alcohols to give the corresponding isocyanates, isocyanato acid chlorides and isocyanato chloroformates. TCF can also be used: To synthesize N-carboxy +a-amino acid anhydrides.As an acylating agent to synthesize oxazolidinones from +a-amino alcohols.As a dehydrating agent to synthesize aromatic diisocyanides in the presence of triethylamine.Easy to handle substitute for phosgene; In-situ charcoal-catalyzed decomposition to phosgene and reaction with amino acids to N-carboxy anhydrides

Specifications

CAS 503-38-8
Density 1.639 g/mL at 20°C
Boiling Point 20°C (10 mmHg, lit.)
Molecular Formula C2Cl4O2
Refractive Index n20/D 1.458
Linear Formula ClCOOCCl3
MDL Number MFCD00015553
Quantity 10 mL
Synonym TCF; Diphosgene; di-Phosgene
Molecular Weight (g/mol) 197.83 g/mol
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