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Cayman Chemical TrIcosnoIc AcId 50mg
Supplier: Cayman Chemical 2686750 MG
An inhibitor of P-gp selectively reverses multidrug resistance mediated by P-gp over MRP1- and BCRP-mediated multidrug resistance resensitizes SKOV3TR and OVCAR-8TR cells to paclitaxel reverses P-gp efflux increasing the intracellular accumulation of P-gp substrates in multidrug resistant SKOV3TR and OVCAR-8TR cells prevents paclitaxel-induced overexpression of MDR1 and P-gp protein level increases in OVCAR-8 cells prevents the development of paclitaxel-induced multidrug resistance in a SKOV3 mouse xenograft model at 50 mg/kg per day in combination with paclitaxel
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