Triethyl 4-phosphonocrotonate, cis + trans, 94%

Description

CAS: 10236-14-3 | C10H19O5P | 250.23 g/mol

Triethyl 4-phosphonocrotonate is used as a reactant for iminodipropionic acid as a leaving group for DNA polymerization by HIV-1 reverse transcriptase, orally bioavailable GPR40 agonist synthesis, preparation of mGlu4R agonists and synthesis of fluoroketone inhibitors of group VIA calcium-independent phospholipase A2.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
Triethyl 4-phosphonocrotonate is used as a reactant for iminodipropionic acid as a leaving group for DNA polymerization by HIV-1 reverse transcriptase, orally bioavailable GPR40 agonist synthesis, preparation of mGlu4R agonists and synthesis of fluoroketone inhibitors of group VIA calcium-independent phospholipase A2.

Notes
Stable under recommended storage conditions. Incompatible with oxidizing agents.

Specifications

Chemical Identifiers

• CAS: 10236-14-3
• Molecular Formula: C10H19O5P
• Molecular Weight (g/mol): 250.23
• MDL Number: MFCD00009192
• InChI Key: LXLODBXSCRTXFG-BQYQJAHWSA-N
• Synonym: triethyl 4-phosphonocrotonate, e-ethyl 4-diethoxyphosphoryl but-2-enoate, ethyl 4-diethoxyphosphoryl but-2-enoate, triethyl .gamma.-phosphonocrotonate, ethyl 4-diethylphosphono crotonate, ethyl 2e-4-diethoxyphosphoryl but-2-enoate, ethyl e-4-diethoxyphosphorylbut-2-enoate, ethyl 4-diethylphosphonocrotonate, ethyl trans-4-diethylphosphono crotonate, 4-diethoxyphosphinyl crotonic acid ethyl ester
• PubChem CID: 5365783
• IUPAC Name: ethyl (E)-4-diethoxyphosphorylbut-2-enoate
• SMILES: CCOC(=O)\C=C\CP(=O)(OCC)OCC

• Density: 1.13
• Boiling Point: 133°C to 135°C (0.4 mmHg)
• Flash Point: >110°C (230°F)
• Refractive Index: 1.455
• Quantity: 10 g
• Formula Weight: 250.23
• Percent Purity: 94%
• Chemical Name or Material: Triethyl 4-phosphonocrotonate, cis + trans

Safety and Handling

Hazard Category	H315-H319-H335
Hazard Statement	GHS H Statement H315-H319-H335 Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.
Precautionary Statement	P261-P264b-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P332+P313-P362-P501c
TSCA	No
Recommended Storage	Ambient temperatures

SDS

RUO – Research Use Only