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Medchemexpress LLC Trifluridine/tipiracil hydrochloride mixture | 733030-01-8 | 99.98% | 435.76 | 100 MG
Supplier: Medchemexpress LLC HY16478100MG
Trifluridine/tipiracil hydrochloride mixture (TAS-102) is a potent and orally active nucleoside antitumor agent. It is a 1:0.5 molar mixture of alpha,alpha,alpha-tri-fluorothymidine (FTD) and thymidine phosphorylase inhibitor (TPI). This mixture primarily exhibits its antitumor activity by inhibiting thymidylate synthase (TS) and incorporating into DNA. It prevents body weight loss and reduces relative tumor volume in colorectal cancer and gastric cancer mouse models.
- Potent and orally active nucleoside antitumor agent.
- Composition: 1:0.5 molar mixture of FTD and TPI.
- Mechanism of action: inhibition of thymidylate synthase (TS) and incorporation into DNA.
- Prevents body weight loss and reduces relative tumor volume in colorectal cancer and gastric cancer mice models.
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