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Medchemexpress LLC Trifluridine/tipiracil hydrochloride mixture | 733030-01-8 | 99.98% | 435.76 | 1ML
Supplier: Medchemexpress LLC HY1647810MM/1ML
Trifluridine/tipiracil hydrochloride mixture (TAS-102) is a potent and orally active nucleoside antitumor agent. It is a 1:0.5 molar mixture of alpha,alpha,alpha-tri-fluorothymidine (FTD) and thymidine phosphorylase inhibitor (TPI). TAS-102 exerts its antitumor activity primarily by inhibiting thymidylate synthase (TS) and incorporating into DNA. In vivo, it has been shown to prevent body weight loss and reduce relative tumor volume in colorectal and gastric cancer mouse models. Several clinical trials are associated with TAS-102 for various conditions like Colorectal Cancer and Gastric Adenocarcinoma.
- Potent and orally active nucleoside antitumor agent
- Mixture of tri-fluorothymidine (FTD) and thymidine phosphorylase inhibitor (TPI)
- Inhibits thymidylate synthase (TS)
- Incorporates into DNA for antitumor activity
- Reduces tumor volume in mouse models
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