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Medchemexpress LLC Trigonelline chloride | 6138-41-6 | 173.60 | 1 ML
Supplier: Medchemexpress LLC HYN041510MM/1ML
Trigonelline chloride is an alkaloid isolated from *Trigonella foenum-graecum* L or *Leonurus artemisia* with potential antidiabetic activity. It functions as a potent Nrf2 inhibitor, blocking Nrf2-dependent proteasome activity to enhance apoptosis in pancreatic cancer cells. It also demonstrates anti-HSV-1, antibacterial, and antifungal properties, and induces ferroptosis. In vitro, it helps rescue H9c2 cell morphology and attenuates H2O2-induced cell deaths, improving antioxidant activity and regulating apoptotic genes.
- Potential antidiabetic activity
- Potent Nrf2 inhibitor, enhancing apoptosis in cancer cells
- Anti-HSV-1, antibacterial, and antifungal activities
- Induces ferroptosis
- Improves antioxidant activity and regulates apoptotic genes
- Affects skeletal system, with varying impacts based on metabolic disorder models
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