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Apexbio Technology LLC Trimethoprim 738-70-5 10g
Supplier: Apexbio Technology LLC B205710000
Trimethoprim (CAS 738-70-5) is a small-molecule inhibitor targeting bacterial dihydrofolate reductase (DHFR) It is designed to selectively inhibit DHFR thereby disrupting folate metabolism and nucleic acid synthesis in bacteria Trimethoprim exerts its biological activity primarily through competitive inhibition of bacterial DHFR In experimental studies trimethoprim demonstrates inhibitory activity with IC50 values ranging from approximately 5 to 15 nM against bacterial DHFR enzymes Based on these pharmacological properties trimethoprim holds research potential in studies of microbiology urinary tract infections bacterial metabolism folate biosynthesis antimicrobial resistance and in the pharmacological profiling of antibacterial agents
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