Sigma Aldrich Trimethyl Orthoformate

Catalog No.	Quantity
30-547-22L	2 L
30-547-2100ML	100 mL
30-547-21L	1 L

Catalog No. 30-547-22L Supplier Sigma Aldrich Supplier No. 3054722L

Description

MilliporeSigma Sigma Organics products encompass a wide range of quality reagents, solvents, catalysts, and building blocks for organic synthesis. From benchtop discovery to process development and scale-up, Sigma Organics solutions are built to meet the needs of synthetic chemists.

Trimethyl orthoformate is a commonly used reagent in organic synthesis for the preparation of useful building blocks. It is also used to introduce the protecting group for aldehydes by the preparation of acetals. Acetals can be deprotected back to the aldehyde by using acid catalysts.Trimethyl orthoformate can be used:To convert sulfonic acids to methyl esters.To convert 2-acylcyclohexanones to the corresponding acetal derivatives.To mediate Pinacol reaction of various 1,2-diols with tin(IV) chloride without the formation of water.To synthesize 1-substituted-1H-1,2,3,4-tetrazoles via a three-component condensation with amine and sodium azide catalyzed by indium triflate under solvent-free conditions.For the N-methylation of amines in the presence of sulfuric acid.

Specifications

• CAS: 149-73-5
• Density: 0.97 g/mL at 25°C
• Boiling Point: 101°C to 102°C
• Molecular Formula: C4H10O3
• Refractive Index: n20/D 1.379
• Linear Formula: CH(OCH3)3
• MDL Number: MFCD00008483
• Quantity: 2 L
• Synonym: TMOF; Trimethoxymethane
• Molecular Weight (g/mol): 106.12 g/mol