Trimethylacetic anhydride, 99%

Catalog No.	Quantity
AAB2298336	500 g
AAB2298314	25 g
AAB2298322	100 g

Catalog No. AAB2298336 Supplier Thermo Scientific Chemicals Supplier No. B2298336

Description

CAS: 1538-75-6 | C10H18O3 | 186.25 g/mol

Trimethylacetic anhydride is used as acylation and esterification reagents. It is involved in acylation and esterification reactions with anilines and phenols. It is also used in solid-phase oligonucleotide synthesis and in the kinetic resolution of racemic 2-hydroxy-gamma-butyrolactones with diphenylacetic acid. It is also employed in the production of cyano-4, N-tert-butyloxycarbonyl piperidine.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
Trimethylacetic anhydride is used as acylation and esterification reagents. It is involved in acylation and esterification reactions with anilines and phenols. It is also used in solid-phase oligonucleotide synthesis and in the kinetic resolution of racemic 2-hydroxy-gamma-butyrolactones with diphenylacetic acid. It is also employed in the production of cyano-4, N-tert-butyloxycarbonyl piperidine.

Solubility
Miscible with acetonitrile.

Notes
Moisture sensitive. Incompatible with strong oxidizing agents, strong acids, strong bases and strong reducing agents.

Specifications

Chemical Identifiers

• CAS: 1538-75-6
• Molecular Formula: C10H18O3
• Molecular Weight (g/mol): 186.25
• MDL Number: MFCD00008842
• InChI Key: PGZVFRAEAAXREB-UHFFFAOYSA-N
• Synonym: pivalic anhydride, trimethylacetic anhydride, 2,2-dimethylpropionic anhydride, propanoic acid, 2,2-dimethyl-, anhydride, pivalic anydride, 2,2-dimethylpropanoic anhydride, trimethylacetic acid anhydride, propanoic acid, 2,2-dimethyl-, 1,1'-anhydride, trimethylaceticanhydride, bispivalic anhydride
• PubChem CID: 15234
• IUPAC Name: 2,2-dimethylpropanoyl 2,2-dimethylpropanoate
• SMILES: CC(C)(C)C(=O)OC(=O)C(C)(C)C

• Density: 0.918
• Boiling Point: 193°C
• Flash Point: 63°C (145°F)
• Odor: Unpleasant
• Refractive Index: 1.409
• Linear Formula: ((CH₃)₃CCO)₂O
• Quantity: 500 g
• UN Number: UN3265
• Beilstein: 386552
• Sensitivity: Moisture sensitive
• Solubility Information: Miscible with acetonitrile.
• Formula Weight: 186.25
• Percent Purity: 99%
• Chemical Name or Material: Trimethylacetic anhydride

Safety and Handling

Hazard Category	H226-H314-H335
Hazard Statement	GHS H Statement H314-H318-H227 Causes severe skin burns and eye damage. Causes serious eye damage. Combustible liquid.
Precautionary Statement	P210-P233-P235-P240-P241-P242-P243-P260-P264b-P271-P280-P301+P330+P331-P303+P361+P353-P304+P340-P305+P351+P338-P310-P363-P370+P378q-P501c
DOTInformation	Hazard Class: 8; Packaging Group: II
EINECSNumber	216-263-1
TSCA	Yes
Recommended Storage	Ambient temperatures

SDS

RUO – Research Use Only